• Cephalosporins are antibiotics that are first-line treatments for pneumonia, urinary tract infections, surgical site infections, and more. However, the current assessment of cephalosporin allergy is not standardized and varies among allergy clinics.
• Cephalosporins share similar chemical structures, so clinicians often unnecessarily avoid a huge class of useful, lifesaving medications.
• DACAT is a clinical research study designed to gather empirical evidence that will allow for a more comprehensive understanding of cephalosporin allergy.

• 6 clinical trial sites across the United States
• 300 participants
• One screening interview followed by 2-4 in-person visits over the course of 1-6 months
• Double-blind skin testing
• Double-blind drug challenges

• Confirm or rule out suspected cephalosporin allergy through drug challenge
• Validate the usefulness of cephalosporin skin testing
• Develop an optimal diagnostic approach to cephalosporin allergy

• Cefazolin (Ancef/Kefzol)
• Ceftriaxone (Rocephin)
• Cephalexin (Keflex)
• Cefdinir (Omnicef)
• Cefaclor (Ceclor/Raniclor)
• Cefepime (Maxipime)

• Ceftazidime (Fortaz/Tazicef/Ceptaz)
• Cefadroxil (Duricef)
• Cefuroxime (Zinacef)
• Cefpodoxime (Vantin)
• Cefixime (Suprax)

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